Shanahan also mentioned that it could be a multi-week injury for Purdy, though he didn’t give an exact timeline for his return. Purdy won’t practice on Wednesday after sustaining multiple injuries in Week 1 against the Seahawks. Jauan Jennings also suffered a shoulder injury in that game and George Kittle landed on injured reserve with a hamstring issue. Mac Jones is in line to make his first start as a 49er and will do so in a relatively easy matchup versus the Saints. Though he is far from a one-for-one replacement for Purdy, Jones should be able to execute the basics of Shanahan’s scheme. He will register as a low-end QB2 for fantasy purposes, making him worth an add in Superflex leagues.

A limited session this early in the week is typically nothing to be concerned with, but Cook’s role is already relatively light with both Ty Johnson and Ray Davis earning a few touches every week. Even a minor decline in usage because of this injury would be a notable blow to his fantasy outlook. Cook only logged 13 carries in Week 1 but managed to find the end zone and pitched in through the air with five receptions. For now, Cook can still be penciled in as a low-end RB1 for Week 2, but fantasy managers will want to keep an eye on the Bills’ injury report for the rest of the week.

Ekeler popped up on the injury report with a shoulder issue earlier this week and was limited for all three practices. It looks like that was all maintenance as he doesn’t have an injury status heading into Thursday’s game. Ekeler earned six carries and three catches in Week 1, ceding 10 carries to rookie Jacory Croskey-Merritt. Even a minor shoulder issue should keep a ceiling on how much work Ekeler sees, relegating him to the RB4 ranks for Week 2.

The good news is that it “is not believed to be a long-term injury” and may not even sideline him for Week 2. However, Goedert has played the entire season just once since entering the NFL in 2018 and it was his rookie campaign. He missed a total of seven games in 2024 with knee and hamstring issues. Goedert got off to a hot start this year with a team-high seven catches in Philly’s Week 1 win over the Cowboys. Even if he is active for Week 2, the veteran tight end will likely take a backseat to Philly’s elite wide receiver duo when they square off against the Chiefs.

Hunter only played six snaps on defense in his NFL debut. Coen said he didn’t expect to use Hunter a ton on defense in Week 1 and it was always the plan to ramp up his defensive snaps as the season progressed. He also noted that the Bengals, Jacksonville’s Week 2 opponent, have a pair of elite wide receivers, further illustrating the team’s need for Hunter to play corner on Sunday. On offense, Hunter was targeted eight times and caught six of his looks, though he only managed 33 yards. Assuming an increase in defensive snaps doesn’t hamstring his role on offense, Hunter is a PPR WR3 for a potential shootout with the Bengals.

Reid noted that Worthy won’t practice on Wednesday, but it’s still as good of an update as you could hope for after seeing the hit he took from Travis Kelce in the Chiefs’ 2025 opener. Kelce and Worthy collided on a crossing route, sending the 165-pound receiver to the turf and ending his night on the first drive. Reid called him day-to-day after the game. It would be a surprise to see Worthy play in Week 2 against the Eagles, but the good news is that this isn’t a long-term issue. The Chiefs would have put Worthy on injured reserve if they were certain he would miss at least four games. For now, Hollywood Brown will be tasked with operating as Kansas City’s No. 1 receiver. Brown saw 16 targets last week, turning them into 10 catches for 99 yards. The target volume alone makes Brown a WR2 for Week 2.

London left the Falcons’ Week 1 loss to the Bucs in the fourth quarter and did not return after being listed as questionable. The contest was nearly over when London went down. It’s possible he could have made his way onto the field had Atlanta forced overtime. Morris mentioned how tough London is and said he also expects him to practice on Wednesday. London earned a massive 36 percent target share in Week 1, good for 15 looks in total. Likely facing negative game script versus the Vikings on the road, he should get peppered with opportunities once again, keeping him in the WR1 ranks despite the minor injury scare.

Daboll was once again effusive with praise for the rookie quarterback, complimenting his work ethic and understand of the team’s offense. “We’ll continue to work with him,” Daboll said. The Giants are almost assuredly prepping Dart to get under center as the team’s starter in the coming weeks following Russell Wilson’s disastrous outing in Week 1 against Washington. Only two QBs were more inaccurate than Wilson last week. Dart should be rostered in all superflex formats. He could have a shot at playing time this week against the Cowboys if things go south for Russ in a hurry.

As long as Nabers practices in full by week’s end, he should be OK for the Giants’ Week 2 game against the Cowboys. Nabers went for five grabs and 71 scoreless yards in Week 1 against the Commanders, leading the team in targets and air yards. Against a Dallas offense that should put up plenty of points this week, Nabers could benefit from a pass-heavy game script. He should be locked into all fantasy lineups.

Miami will likely be without Jackson and RG James Daniels, who was placed on injured reserve this week with a pectoral injury. It’s a major blow to the Dolphins offense, which struggled mightily in their Week 1 blowout loss to Daniel Jones and the Colts. Tua Tagovailoa in Week 1 was pressured on just 22 percent of his drop backs, the third lowest rate in the league. The team’s quick-passing offense should prevent Tagovailoa from facing much pressure this week against New England.